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2022 NFL Week 13 Predictions, Odds and Betting Previews

Semana 13 de la NFL
A general interior view of Gillette Stadium with the sun reflecting off the upper windows during the second half of an NFL football game between the New England Patriots and the New York Jets, Sunday, Nov. 20, 2022, in Foxborough, Mass. (AP Photo/Greg M. Cooper)

Week 13 of the NFL’s 2022 season signals the start of the season’s final stretch after Week 12 saw significant developments across the league. As usual, JefeBet brings you the best predictions for this new NFL week for all games that will be played throughout the following days.

A total of 15 games will be played between November 24 and 28, taking into account that the Arizona Cardinals and Carolina Panthers are off this week. Without further ado, here are our predictions for NFL Week 13.

All odds shown are courtesy of BetMGM.

Predictions, Odds and Betting Previews for All 2022 NFL Week 13 Games

Buffalo Bills (-210) vs New England Patriots (+170) / Thursday, December 1 / 8:15 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Bills Spread: -5.0.
  • Patriots Spread: +5.0.
  • Over/Under: 43.5

Week 13 of the NFL will kick off with a heart-stopping Thursday Night Football when the Bills and Patriots face off in a divisional matchup that could define postseason berths.

Buffalo hasn’t been as solid as many expected, and they sit second in the AFC East with the same record as the Dolphins, 8-3. The Bills have won two games in a row and have scored more than 28 points in the last three games; meanwhile, their solid defense has allowed more than 23 touchdowns only twice, and only once did the opponent surpass 400 total yards.

New England, meanwhile, halted a streak of three consecutive wins and momentarily dropped out of the postseason picture by falling to the bottom of the division with a 6-5 record. The Patriots’ solid defense didn’t have a good night against the Vikings, something that helped the Bengals take the final wild card spot in the AFC. Bill Belichick’s team is the defense with the fewest penalties, and in the last seven games they have allowed more than 17 points only twice, a performance that does not go hand in hand with one of the weakest offenses in the circuit.

Prediction: Bills spread.

[Bills vs Patriots NFL Week 13 full betting preview here]

Pittsburgh Steelers (+105) vs Atlanta Falcons (-125) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Steelers Spread: +1.5.
  • Falcons Spread: -1.5.
  • Over/Under: 42.

NFL Week 13 continues with a crucial matchup for the Falcons when they host the Steelers on Sunday.

Pittsburgh is coming off its second win in the last three games with a 4-7 victory over the Colts on Monday Night Football. The Steelers defense was again the star of the night against Indianapolis and for the fourth time in the last six games they conceded less than 18 points. On the offensive side, they have started to play much better even though their star running back, Najee Harris, was injured.

For their part, the Falcons incredibly maintain their hopes of catching the Buccaneers in the NFC South despite losing for the third time in their last four games and having a 5-7 record. Atlanta has failed to score more than 17 points in four of its last six games, while its defense has only limited opponents to 20 points or fewer four times this season.

Prediction: Over.

[Steelers vs Falcons NFL Week 13 full betting preview here]

Denver Broncos (+300) vs Baltimore Ravens (-400) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Broncos Spread: +8.0.
  • Ravens Spread: -8.0.
  • Over/Under: 38.5.

In another exciting NFL Week 13 matchup next Sunday, the Broncos will have a tough matchup when they visit the Ravens.

Denver now sits comfortably in last place in the AFC West with a 3-8 record after suffering their third consecutive defeat. Russell Wilson and company have been a real offensive disaster, and for the fourth time this year they failed to surpass 10 points scored in a game. Moreover, they failed to reach 300 total yards for the fourth time. The defense is still one of the best in the league, but if points aren’t scored, all efforts are in vain.

The Ravens, meanwhile, will be seeking revenge at home following their unexpected defeat in Jacksonville, which complicated matters in their division. With a 7-4 record, Baltimore and the Bengals are tied for first place in the AFC North and will face off in the last championship week. The Jaguars stunned an offense that had scored 27 points for the third time in the previous four games with 18 points in the fourth quarter.

Prediction: Ravens Spread.

[Broncos vs Ravens NFL Week 13 full betting preview here]

Green Bay Packers (-135) vs Chicago Bears (+115) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Packers Spread: -2.5.
  • Bears Spread: +2.5.
  • Over/Under: 42.5

Who would have thought that this week’s matchup between the Packers and Bears would define the team that will wake up next Monday as the NFC North runner-up?

Green Bay will play at Chicago with a 4-8 record after losing seven of its last eight games. In addition, the Packers’ depleted offense may be without Aaron Rodgers, who was injured Sunday against the Eagles. They scored more than 30 points against Philadelphia for the second time this season, and in five of their last seven games, they haven’t gone over 21. How does the defense fare? Only three times have the opponents scored less than 23 points against them, and Philadelphia has scored 40 goals against those opponents.

On the Bears’ side, the situation is not getting any better either. They have lost five games in a row to stand at 3-9 and QB Justin Fields’ participation is also in doubt after missing Sunday’s game against the Jets. The Bears had improved a lot on offense in recent weeks, but their defense fell apart and even against the Jets, one of the least solid offenses in the league, they were unable to avoid conceding more than 30 points for the fourth time in the last five games.

Prediction: Over.

[Packers vs Bears NFL Week 13 full betting preview here]

Jacksonville Jaguars (-105) vs Detroit Lions (-115) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Jaguars Spread: +1.0.
  • Lions Spread: -1.0.
  • Over/Under: 51.5 Points

The Jaguars and Lions’ pride will be on the line this coming Sunday when both teams, out of postseason contention, meet in NFL Week 13.

Jacksonville is coming off a hard-fought 27-28 win over the Ravens to bring their record to 4-7. The Jaguars have seen a considerable improvement in their performance this season, and none of their seven losses have come by more than 10 points, something that speaks to the good work of Doug Pederson as head coach. Probably the point to be addressed is the defense, which has not conceded less than 20 points to an opponent in six weeks.

For their part, Detroit has shown good things this year, especially on offense, but their defense has been a disaster and that is why they come into this game with a 4-7 record after losing to the Bills. Despite scoring at least 25 points for the fourth time in their last five games, the Lions fell short of pulling off the shocking victory of the week against Buffalo. The defense’s failure to stop opponents from gaining more than 400 total yards for the third game in a row is to blame for that.

Prediction: Over.

[Jaguars vs Lions NFL Week 13 full betting preview here]

Cleveland Browns (-350) vs Houston Texans (+260) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Browns Spread: -7.0.
  • Texans Spread: +7.0.
  • Over/Under: 46.5

The possibility of Deshaun Watson making his Cleveland debut against his former team will be the main draw of this Browns-Texans game.

After serving a 12-week suspension, the quarterback seems prepared to lead a team that just defeated the Buccaneers in overtime but doesn’t stand a chance of making the playoffs with a 4-7 record. Only twice this season have the Browns scored fewer than 20 points, but five times their defense has allowed opponents to score more than 30 points. This is their primary cause of failure.

On the Texans’ side, they are all but assured of the worst record in the league at 1-9-1 and thus the first overall pick in the upcoming NFL Draft. Houston’s offense is a real pain and only on one occasion were they able to pass the 20-point threshold, while their defense has not been entirely successful either and in five of the last six games they have conceded more than 23 points to opposing teams.

Prediction: Browns spread.

[Browns vs Texans NFL Week 13 full betting preview here]

New York Jets (+140) vs Minnesota Vikings (-165) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Jets Spread: +3.0.
  • Vikings Spread: -3.0.
  • Over/Under: 45.5

The Vikings and Jets are headed for postseason play this coming Sunday in an extremely important matchup for both teams.

The New York team re-entered the AFC Wild Card bracket with a 31-10 win over the Bears, which leaves them with a 7-4 record. Giving Mike White the start over Zach Wilson seems to have helped awaken a weak Jets’ offense, which had only scored three points against the Patriots two weeks ago. However, defense continues to be this team’s main weapon and for the fourth time in the last four games they allowed 10 points or fewer to their opponents.

On the Vikings’ side, they quickly overcame the beating by the Cowboys and ended up beating the Patriots 26-32 to remain the second-best team in the NFC with a 9-2 record. While Minnesota’s defense continues to suffer and allowed 26 points to a weak New England offense, the offense came alive with its third 30-plus point game in the last five games.

Prediction: Over.

[Jets vs Vikings NFL Week 13 full betting preview here]

Washington Commanders (-135) vs New York Giants (+110) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Spread Commanders: -1.5.
  • Giants Spread: +1.5.
  • Over/Under: 40.5

With all four teams in the NFC East qualified for the postseason, this is currently the strongest division in the NFL. This Sunday, two of those teams, the Commanders and Giants, will play each other on the field.

Thanks to six wins in the last seven games, Washington is the third wild card in the National Conference with a 7-5 record and might keep climbing positions with a win against the Giants. Since Taylor Heinicke took over as the team’s starting QB, the Commanders’ offense has been different. But this team’s success is mostly due to its defense, which has allowed 21 points or fewer in eight of its games and allowed no opponent to score more than 13 points in the previous two matchups.

Meanwhile, the Giants have lost ground in the NFC East with two consecutive losses that have them in third place in the group with a 7-4 record and the second wild card in the conference. While the offense has been held under 21 points in three of those last four games, in those three losses the opponents have managed to score at least 27 points.

Prediction: Over.

[Commanders vs Giants NFL Week 13 full betting preview here]

Tennessee Titans (+200) vs Philadelphia Eagles (-250) / Sunday, December 4 / 1:00 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Titans Spread: +5.5.
  • Eagles Spread: -5.5.
  • Over/Under: 44.5.

Next Sunday’s game between the Titans and Eagles is anticipated to be fantastic, since both teams are at the top of their respective divisions.

The Tennessee team cut short a string of two wins by failing to beat the Bengals 20-16 at home to fall to a 7-4 mark. Despite this result, they are comfortable leaders of the AFC South and are on their way to another postseason after being the best record in the conference last year. However, their offensive performance is a concern, as they have failed to score more than 20 points in five of their last six games. So, how are they leading? Their defense, especially on the ground, is a real wall.

On the Philadelphia side, they still have the best record in the NFL with a 10-1 record after defeating the Packers 33-40. While allowing the second most points on the season, the Eagles managed 500 total yards on offense, 353 of those rushing, thanks to another big night from Jalen Hurts. This is indeed a very complete team with very few flaws on both sides of the gridiron.

Prediction: Under.

[Titans vs Eagles NFL Week 13 full betting preview here]

Seattle Seahawks (-225) vs Los Angeles Rams (+180) / Sunday, December 4 / 4:05 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Seahawks Spread: -5.5.
  • Rams Spread: +5.5.
  • Over/Under: 40.5

In a showdown between divisional rivals in the NFC West this Sunday, the Seahawks and Rams will meet on the gridiron.

Seattle was left out from the postseason last weekend after losing to the Raiders in overtime for the second week in a row. However, the Seahawks still have a chance to make the playoffs and must produce a strong offensive performance against the struggling Rams. Los Angeles has one of the worst offenses in the league, but Seattle’s main issue is their defense, particularly on the ground.

Indeed, as you just read. The defending champions have suffered five straight defeats and are currently last in their division with a 3-8 record. Without Matthew Stafford and Cooper Kupp, the Rams have scored more than 20 points only twice this season, a performance that hasn’t been matched by the good work of their defense, which, while not as elite as last season’s, is still among the best in the league.

Prediction: Seahawks to win.

[Seahawks vs Rams NFL Week 13 full betting preview]

Miami Dolphins (+150) vs San Francisco 49ers (-185) / Sunday, December 4 / 4:05 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Dolphins Spread: +3.5
  • 49ers Spread: -3.5.
  • Over/Under: 46.5

Week 13 of the NFL is packed with big games, one of them being the match between two division leaders such as the Dolphins and 49ers.

Thanks to an amazing passing offense, Miami has won five consecutive games and leads the AFC East over the Bills by a head-to-head score of 8-3. The Dolphins scored over 30 points against Houston for the fourth straight game, and their Achilles’ heel defense, which has allowed fewer than 17 points in each of the last two games, has shown signs of improvement.

Meanwhile, the 49ers moved into sole possession of first place in the NFC West with their fourth consecutive win by blanking the Saints 0-13 to move to 7-4. No opponent has scored more than 16 points against them during San Francisco’s winning streak, making them the league’s best defensive team at the moment. Additionally, Jimmy-G has done a fantastic job, and the addition of Christian McCaffrey has completely changed the offense.

Prediction: Over.

[Dolphins vs 49ers NFL Week 13 full betting preview here]

Kansas City Chiefs (-145) vs Cincinnati Bengals (+120) / Sunday, December 4 / 4:25 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Chiefs Spread: -2.5.
  • Bengals Spread: +2.5.
  • Over/Under: 52.5.

The Chiefs vs Bengals, teams that last year played a great AFC Conference Final with Cincinnati winning, will square off in another thrilling matchup this coming Sunday.

In addition to having a five-game winning streak and a desire for retribution, Kansas City also enters with the best 9-2 record in the American Conference and has no desire to slide down the rankings. They have the best offense in the league, which is led by Patrick Mahomes, who is the front-runner to win the MVP award at the end of the season. Although the Chiefs’ defense is not among the best, it is more than adequate if we consider that the team ranks first in terms of points scored despite giving an average performance.

As for Cincinnati, they are coming off a 20-16 victory over the Titans for their third consecutive win and to tie for the lead in the AFC North with the Ravens, who are ahead of them in the head-to-head series despite the fact that both have 7-4 records. The powerful Bengals offense could only score 20 points against Tennessee, but their defense allowed less than 17 points for the second time in the last five games .

Prediction: Over.

[Chiefs vs Bengals NFL Week 13 full betting preview here]

Los Angeles Chargers (-125) vs Las Vegas Raiders (+105) / Sunday, December 4 / 4:25 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Chargers Spread: -2.0.
  • Raiders Spread: +2.0.
  • Over/Under: 50.5 Points

For the second time this season, the Chargers and the Raiders will face each other in an interesting duel between two AFC West rivals.

Los Angeles, which ended a two-game losing streak by defeating the Cardinals 25-24 to fall to 6-5, still has a chance to advance into a postseason spot. While playing away is always difficult, the Chargers have won four games on the road, and what Justin Herbert can do against the Raiders’ inconsistent defense will be the key on Sunday.

For their part, the Raiders seem to have bounced back and have won two consecutive victories, both in overtime, to move to a 4-7 record. Derek Carr and company totaled more than 400 yards for the second consecutive game, including 576 in the win over the Seahawks. The detail is that in the last seven games, only twice has the defense allowed less than 24 points to the opponent .

Prediction: Over.

[Chargers vs Raiders NFL Week 13 full betting preview here]

Indianapolis Colts (+325) vs Dallas Cowboys (-400) / Sunday, December 4 / 8:20 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Colts Spread: +9.5.
  • Cowboys Spread: -9.5.
  • Over/Under: 43.5

The Colts and Cowboys’ Sunday Night Football matchup in primetime is predicted to go one way in NFL Week 13.

Indianapolis missed a great opportunity to cut into the Titans’ lead and fell at home to the Steelers to move to a 4-7-1 record. The Colts continue to struggle offensively and for the tenth time in 12 games failed to score more than 20 points. The defense continues to do a good job, but in truth, the offensive support has been nil throughout the season.

As for Dallas, they have won two in a row by beating the Giants to take sole possession of second place in the hard-fought NFC East. While their defense continues to stop opponents at will, the Cowboys have not scored fewer than 28 points in any of their last four games, which has caused a lot of fear among National Conference opponents.

Prediction: Cowboys Spread.

[Colts vs Cowboys NFL Week 13 full betting preview here]

New Orleans Saints (+155) vs Tampa Bay Buccaneers (-190) / Monday, December 5 / 8:15 PM E.T.

NFL Week 13 Predictions Odds Betting Previews
  • Saints Spread: +3.5.
  • Buccaneers Spread: -3.5.
  • Over/Under: 40.5

NFC South’s Monday Night Football, which features a game between the Saints and Buccaneers, will end NFL Week 13.

The New Orleans team is one of the big disappointments of the season after being blanked 0-13 by the 49ers last weekend and thus remaining in last place in the division with a 4-8 record. The amazing part of it all is that if they win, they would only be one half a game behind Tampa Bay. To do so, they must improve a lot on offense, since in the last four games they have only once scored more than 13 points, and in the first game against the Bucs they scored only 10.

With a 5-6 record, the Buccaneers are the leaders of the worst division in the NFL and it is imperative that they win this home game to make an impact on the group. Tampa Bay is coming off an overtime loss to the Browns and could only score 17 points against a very weak Cleveland defense. While Tom Brady should strive to get better, it is crucial that his powerful defense doesn’t allow any action from the Saints.

Prediction: Buccaneers to win.

[Saints vs Buccaneers NFL Week 13 full betting preview here]

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