After pulling off a stunning upset win in Week 3, the Arizona Cardinals have another chance to slay a giant this weekend when they take on the undefeated San Francisco 49ers in Santa Clara. Will the Cardinals shock everyone again with a victory? Or will the Niners handle their business just fine?
Read on for more about this Cardinals vs 49ers matchup in the 2023 NFL game, including our predictions, picks, and latest odds to win this showdown, as brought to you by JefeBet. Also, don’t forget to check out other NFL content to help you make the best betting decisions.
Predictions, Odds, and Betting Preview for the Arizona Cardinals vs San Francisco 49ers NFL Regular Season Week 4 Game on October 1, 2023
- Where: Levi’s Stadium, Santa Clara, California
- When: Sunday, October 1, 2023, 4:25 PM ET
- Where to Watch: FOX
- Spread: Arizona Cardinals (+14) vs San Francisco 49ers (-14)
- Over/Under: 44.0
All odds are provided by DraftKings.
Betting on the Arizona Cardinals (+14)
Regular season record: 1-2
There is a case to be made that the Cardinals could have been 3-0 instead of 1-2 at this point of the season. Nevertheless, the Cardinals are finally in the win column after stunning the Dallas Cowboys in a 28-16 home win last Sunday.
Arizona has yet to look thoroughly outclassed this season despite low expectations of the team prior to Week 1. Their two losses to the Washington Commanders and the New York Giants were by a combined margin of just seven points. Arizona is minimizing the impact of a lack of t talent on the roster with elite ball security, as the Cardinals are sixth in the league with only 0.7 giveaways per game.
Betting on the San Francisco 49ers (-14)
Regular season record: 3-0
San Francisco is looking scary. The 49ers are playing like they are a legitimate contender to win the Super Bowl. Brock Purdy has been steady under center for them, as he now has passed for 736 yards and four touchdowns with zero interceptions through three games this season.
In the Niners’ 30-12 home win over the Giants in Week 3, Purdy went 25/37 for 310 yards, two touchdowns, and zero picks. His job on offense gets easier because of running back Christian McCaffrey, who leads the NFL with 353 rushing yards. San Francisco’s greatness is also being felt on the other side of the field. The 49ers, who are third in the league with 30.0 points per game, are also top-five in the NFL with just 14.0 points allowed per contest.
El Jefe’s Prediction on Arizona Cardinals vs San Francisco 49ers
This will be the game where the Cardinals will finally look overmatched. San Francisco exposes Arizona for a crushing victory.
The 49ers win, 30-13.
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