San Francisco 49ers vs Denver Broncos Predictions, Picks, Odds, and Betting Preview | NFL Week 3 2022

San Francisco 49ers vs Denver Broncos
NFL preseason football game between the Denver Broncos and the San Francisco 49ers, Monday, Aug. 19, 2019, in Denver. (AP Photo/Jack Dempsey)

The 49ers vs Broncos meet on Sunday Night Football in Week 3 of the NFL season in a crucial showdown between two teams with postseason aspirations.

The 49ers are coming off a convincing 27-7 win over their division rivals, the Seattle Seahawks, after being surprised in Week 1 by the Bears. For their part, the Broncos recovered from their loss to Seattle and defeated the Texans, with many doubts, by a score of 16-9.

After this short recap, JefeBet presents below the 49ers vs Broncos predictions and betting preview.

Predictions and Betting Preview for the San Francisco 49ers vs Denver Broncos NFL Week 3 Game on September 25 2022

49ers vs Broncos Predictions Picks Betting Odds
  • Where: Empower Field at Mile High – Denver, Colorado.
  • When: Sunday, September 25, 2022, 8:20 PM E.T.

Odds courtesy of BetMGM and Unibet, we invite you to read our reviews.

Betting on the San Francisco 49ers

49ers vs Broncos Predictions Picks Betting Odds
  • Regular Season Record: 1-1
  • BetMGM Spread: -1.5.
  • Moneyline: (-120).
  • Over/Under: 45.5.

San Francisco heads into Week 3 with Jimmy Garoppolo as its starting quarterback for the remainder of the season after young Trey Lance, who had won the starting QB job, fractured his ankle against the Seahawks causing him to miss all of 2022.

Garoppolo immediately took command of the offense and guided his team to an important victory at home, adding the first win and giving them more confidence for next Sunday’s game. Jimmy-G completed 13 of 21 passes for 154 yards, scored one touchdown, and added another on the ground. San Francisco must trust him again, and the game against Denver will be an excellent opportunity for him to demonstrate his abilities.

The 49ers’ defense was also up to the task and the seven points the Seahawks scored came on a kickoff return after a blocked field goal. Seattle totaled just 216 total yards and lost the ball three times. Against the Broncos, who have failed to score more than 16 points in each of their games, it could be a good time to keep the momentum going.

Betting on the Denver Broncos

49ers vs Broncos Predictions Picks Betting Odds
  • Regular Season Record: 1-1
  • Spread: +1.5.
  • Unibet Moneyline: (+102).
  • Over/Under: 45.5.

The Russell Wilson era in Denver hasn’t started very well. Despite winning their first game of the season last Sunday, the Broncos’ offense has not lived up to expectations on The High Mile.

Although the quarterback threw for 216 yards, with a touchdown and an interception, it was not until the fourth period that the Broncos were able to settle the game. Entering that quarter, they were down 9-6 and their 10 unanswered points sealed a pretty tough win against a Texans team that failed to score a touchdown.

It was Denver’s defense that kept the game alive after stopping David Mills and holding Houston to just 234 total yards, almost as many as Wilson threw for the game. The test will be a little stiffer this Sunday, again at home, with the presence of Garoppolo and the versatile Deebo Samuel.

JefeBet Prediction

Although both teams have very good quarterbacks leading their offenses, Monday night’s game promises to be a battle of defenses. Neither the 49ers nor the Broncos have allowed more than 20 points this season. Additionally, both teams have seen the under in each of their games and in the two lifetime clashes they have played in Denver the under has been given up.

49ers vs Broncos Predictions: Under (SF 24 – DEN 17).


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