Cleveland Guardians vs Chicago White Sox Prediction, Pick, Odds, and Best Bets | Sep 21 2022

Guardians vs White Sox Best Bets and Betting Odds

The Chicago White Sox (76-71) will take on the Cleveland Guardians (80-67) on Wednesday, September 21 at Guaranteed Rate Field in Chicago. As they work their way through the final third of the season, each of these ball clubs will surely be searching for a victory in this regular season game. Be sure to catch the action at 7:10 PM CT!

Let’s take a peek at how Chicago and Cleveland have fared against each other in the past for context heading into Wednesday’s regular season meeting.

This season, these ball clubs have battled in 10 matchups, and the White Sox have claimed victory six times against their opponents. When they last met on on Thursday, the Cleveland Guardians came up victorious to the tune of 2-8. The White Sox had 11 runs and 12 hits, while the Guardians tallied 0 runs on three hits. We’ll see who comes out victorious this time when these two teams square off at Guaranteed Rate Field.

Betting Preview for the Cleveland Guardians vs Chicago White Sox MLB Game on September 21 2022

Where: Guaranteed Rate Field in Chicago, IL

When: Wednesday, September 21, 2022 at 7:10 PM CT

Betting on the Cleveland Guardians

Record: (80W-67L) | American League Central Standing: 1

The Guardians defeated the Minnesota Twins 11-4 in their most recent outing on Monday, and we’ll be interested to see if this momentum continues. Overall this season, the Guardians are currently batting .253 due in large part to their hottest bat, Andrés Giménez, who is riding high with a batting average of .298. In terms of defense, they have an ERA of 3.57 and a .984 fielding percentage. Prior to placing your bet, don’t forget to review our odds assessment below!

Absences and Injuries

It’s confirmed that the Guardians are without Anthony Gose (Triceps) and Zach Plesac (Hand).

Betting on the Chicago White Sox

Record: (76W-71L) | American League Central Standing: 2

In their most recent game on Sunday, the White Sox lost to the Detroit Tigers by a score of 5-11. Overall this season, the White Sox are currently batting .260 thanks in large part to their top hitter, José Abreu, who leads the team with a batting average of .303. Defensively, they carry an ERA of 3.86 and a .981 fielding percentage. Make sure you explore our odds analysis below before selecting your picks!

Absences and Injuries

With respect to inactive players in this game, the White Sox are without Kyle Crick (Elbow), Jonathan Stiever (Lat), Michael Kopech (Shoulder), Johnny Cueto (Illness), Timothy Anderson (Finger), Garrett Crochet (Elbow), and Daniel Mendick (Knee).

Cleveland Guardians vs Chicago White Sox | Moneyline, Over/Under and Point Spread Odds

Moneyline Pick: Chicago White Sox (-174) at FanDuel

The White Sox are considered the favorite in this regular season game. The club is having a good September so far, entering this matchup as they sport a winning percentage of 72.22% for this month, a record of 13 victories in total. they’ve played. In comparison, the Guardians’ winning percentage is less at 63.16% for this month, accounting a total of 12 wins.

Over/Under Pick: Under 7.5 Total Runs (-120) at Bovada

In this matchup, we estimate that the combined total number of runs scored for both teams will be under 7.5. Be sure to take this into account when placing your bet!

Runline Pick: Cleveland Guardians -1.5 Runs (+370) at Unibet

The Cleveland Guardians will need to win by the amount of the spread or more in order to cover a runline of -1.5.

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