Cleveland Guardians vs Chicago White Sox Prediction, Pick, Odds, and Best Bets | Sep 22 2022

Guardians vs White Sox Best Bets and Betting Odds

The Chicago White Sox (76-72) will once again host the Cleveland Guardians (81-67) on Thursday, September 22 at Guaranteed Rate Field in Chicago. As they work their way through the final third of the season, each of these teams will surely be vying for a win in this regular season game. Get your picks in and catch the action when it all goes down at 7:10 PM CT!

Take a look at how the White Sox and Guardians have fared against each other in the past for context about Thursday’s regular season matchup.

So far this season, these teams have played in 10 contests, and the White Sox have earned a win five times against their opponents. In their previous meeting on Wednesday, the Chicago White Sox came out on top to the tune of 2-8. The White Sox had seven runs and 10 hits, whereas the Guardians tallied 10 runs on 11 hits. We’ll see who comes out victorious this time when these two teams go head to head at Guaranteed Rate Field.

Betting Preview for the Cleveland Guardians vs Chicago White Sox MLB Game on September 22 2022

Where: Guaranteed Rate Field in Chicago, IL

When: Thursday, September 22, 2022 at 7:10 PM CT

Betting on the Cleveland Guardians

Record: (82W-67L) | American League Central Standing: 1

The Guardians lost to the Chicago White Sox 7-10 in their most recent outing on Tuesday, and we can’t wait to find out if they can come away victorious in this one. Overall this season, the Guardians are currently batting .254 due in large part to their hottest bat, Andrés Giménez, who leads the team with a batting average of .299. Defensively, they have an ERA of 3.55 and a .984 fielding percentage. Before you place your bet, don’t forget to consult our odds assessment below!

Absences and Injuries

Per the latest inactive report, the Guardians are missing Anthony Gose (Triceps) and Zach Plesac (Hand).

Betting on the Chicago White Sox

Record: (76W-73L) | American League Central Standing: 2

In their last game on Tuesday, the White Sox beat the Cleveland Guardians by a score of 7-10. Overall this season, the White Sox are currently batting .260 thanks in large part to their top hitter, José Abreu, who has a batting average of .302. In terms of defense, they carry an ERA of 3.89 and a .981 fielding percentage. Be sure to check out our odds analysis further down before selecting your picks!

Absences and Injuries

It’s confirmed that the White Sox will play without Kyle Crick (Elbow), Jonathan Stiever (Lat), Michael Kopech (Shoulder), Johnny Cueto (Illness), Timothy Anderson (Finger), Garrett Crochet (Elbow), and Daniel Mendick (Knee).

Cleveland Guardians vs Chicago White Sox | Moneyline, Over/Under and Point Spread Odds

Moneyline Pick: Cleveland Guardians (-142) at FanDuel

The Guardians are considered the favorite by many baseball fans and oddsmakers in this regular season showdown. The club is enjoying a productive September so far, entering the game with a winning percentage of 66.67% for this month, accounting a total of 14 wins. they’ve played. On the other side of things, the White Sox’s winning percentage is at 65% for this month, a record of 13 victories in total.

Over/Under Pick: Under 7.5 Total Runs (-122) at FanDuel

In this matchup, we are predicting that the combined total number of runs scored for both teams will be under 7.5. Be sure to take this into account when placing your bet!

Runline Pick: Cleveland Guardians -1.5 Runs (+126) at FanDuel

The Cleveland Guardians will need to win by the amount of the spread or more in order to cover the oddsmakers’ runline of -1.5.

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