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Buffalo Bills vs Detroit Lions | Best Bets and Betting Odds | NFL Week 12

The Detroit Lions (4W-6L) will meet the Buffalo Bills (7W-3L) in Detroit on Thursday, November 24 at Ford Field. Of course, each of these teams will be trying to secure a win, so keep this top of mind when placing your bets and then follow the action live at 12:30 PM ET!

For context related to this matchup, let’s examine how the Lions and the Bills have performed versus each other historically. While the teams have competed in three contests over the past few years, the home team in this game, the Lions, have been defeated in each game against their opponents. In their most recent meeting on August 13, 2021, the end result was 15-16 in favor of the Bills.

Betting Preview for the Buffalo Bills vs Detroit Lions NFL Week 12 Game on November 24 2022

Where: Ford Field in Detroit, Michigan

When: Thursday, November 24, 2022 at 12:30 PM ET

Betting on the Buffalo Bills

Regular Season Record: (7W-3L) | American Football Conference Standing: 5

The Buffalo Bills have had some recent ups and downs and are currently in 2nd place in the AFC East. In their most recent game on Sunday, November 20, the Bills defeated the Cleveland Browns 31-23. Do you think the story will be the same this week?

On the offensive side of the ball, the Bills are averaging 293.8 passing yards per game and 5.32 yards per rush attempt. With a turnover margin of -0.4, Buffalo has held an average of 29:39 in possession time this season.

Absences and Injuries

As for inactive players, the Bills are without Jamison Crowder (Ankle), Josh Allen (Elbow), Ike Boettger (Achilles), Tommy Doyle (Knee – ACL), Tremaine Edmunds (Groin), A.J. Epenesa (Ankle), Micah Hyde (Neck), Jake Kumerow (Ankle), Mitch Morse (Elbow), Marquez Stevenson (Foot), and David Quessenberry (Ankle).

Betting on the Detroit Lions

Regular Season Record: (4W-6L) | National Football Conference Standing: 10

The Detroit Lions have experienced a varying degree of wins and losses lately and are ready to move up in the standings when all is said and done. In their latest appearance on Sunday, November 20, the Lions outplayed the New York Giants by a score of 18-31, and we can’t wait to see what happens when they square off against the Bills in this Week 12 matchup.

So far this season, the Lions are averaging 244.8 passing yards per game and 4.81 yards per rushing attempt. With an average possession time of 29:03, Detroit is carrying a turnover margin of -0.2.

Absences and Injuries

The Lions will play without Trinity Benson (Knee), Evan Brown (Ankle), Quintez Cephus (Foot), Charles Harris (Groin), Jonah Jackson (Illness), D.j. Chark (Ankle), Tommy Kraemer (Back), Romeo Okwara (Achilles), Levi Onwuzurike (Back), Bobby Price (Knee), Frank Ragnow (Foot), Craig Reynolds (Ribs), Josh Reynolds (Back), Halapoulivaati Vaitai (Back), Tracy Walker (Achilles), Jameson Williams (Knee – ACL), and Greg Bell (Hamstring).

Buffalo Bills vs Detroit Lions | Moneyline, Over/Under and Point Spread Odds

Moneyline Pick: Buffalo Bills (-460) at FanDuel

The Bills are considered the favorite. The team enters the game with a winning percentage of 70%. On the other sideline, the Lions’ winning percentage is 40%.

Over/Under Pick: Under 54.5 Points (-112) at FanDuel

The Detroit Lions have recorded an average of 25.0 points per game during the regular season. In comparison, the Buffalo Bills have logged 28.1 points.

Spread Pick: Buffalo Bills -9.5 Points (-110) at FanDuel

The Buffalo Bills will need to win by the amount of the spread or more in order to cover.

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