Buffalo Bills vs Los Angeles Rams Prediction, Pick, Odds, and Best Bets | NFL Week 1 2022

Bills vs Rams Best Bets and Betting Odds

The Los Angeles Rams will take on the Buffalo Bills in Inglewood on Thursday, September 8 at SoFi Stadium in Week 1. Both teams will try to set the tone for the season with a win, so remember to place your bets and then make sure to watch the action unfold at 5:20 PM PT!

For context related to this game, let’s see how the Rams and the Bills have stacked up against each other in the past. While these organizations have battled in one contest over the past few years, the home team, the Rams, lost to their opponents. In their latest meeting on September 27, 2020, the score was 35-32 in favor of the Buffalo Bills.

Betting Preview for the Buffalo Bills vs Los Angeles Rams NFL Week 1 Game on September 8 2022

Where: SoFi Stadium in Inglewood, California

When: Thursday, September 8, 2022 at 5:20 PM PT

Betting on the Buffalo Bills

In their last game on Friday, August 26, the Bills were beaten by the Carolina Panthers 21-0. The Bills gained 146 passing yards and averaged 3.24 yards per rush attempt. The group had 4 turnovers and a possession time of 30:01. Will this all be enough going into the start of the regular season though?

Absences and Injuries

As for inactive players, the Bills are without Ike Boettger (Achilles), Tommy Doyle (Foot), Quintin Morris (Hamstring), Marquez Stevenson (Foot), and Tre’Davious White (Knee – ACL).

Betting on the Los Angeles Rams

In their most recent game on Saturday, August 27, the Rams lost to the Cincinnati Bengals 16-7. In that game, the Rams gained 143 passing yards and averaged 3.77 yards per rush attempt. They had 0 turnovers and a possession time of 29:02. That said, are they ready to start the season off on the right foot?

Absences and Injuries

The Rams will play without Travin Howard (Groin), Van Jefferson (Knee), Xavier Jones (Achilles), Logan Bruss (Knee), Daniel Hardy (Ankle), and Quentin Lake (Knee).

Buffalo Bills vs Los Angeles Rams | Moneyline, Over/Under and Point Spread Odds

Moneyline Pick: Buffalo Bills (-134) at FanDuel

The Buffalo Bills are considered the favorite per oddsmakers for this matchup. Do you think the game will go their way?

Over/Under Pick: Under 51.5 Points (-106) at FanDuel

We evaluated the number of points to be under 51.5 for this football game. Keep it in mind while placing your bet!

Spread Pick: Buffalo Bills -2.5 Points (-110) at FanDuel

The Buffalo Bills will need to win by the amount of the spread or more in order to cover.

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