Indianapolis Colts vs Buffalo Bills Prediction, Pick, Odds, and Best Bets | NFL Preseason 2022

Colts vs Bills Best Bets and Betting Odds

The Buffalo Bills will host the Indianapolis Colts in their first preseason game on Saturday, August 13 at Highmark Stadium in Orchard Park. No doubt each of these teams will be searching for a win as we prepare for the regular season, so don’t forget to place your bets and then catch the excitement live at 4:00 PM ET!

For context about to this game, how have the Bills and the Colts performed versus each other in the past? While these organizations have played in four contests over the past few years, the home team, the Bills, have claimed victory twice against their opponents. In their latest meeting on November 21, 2021, the score was 15-41 in favor of the Indianapolis Colts.

Betting Preview for the Indianapolis Colts vs Buffalo Bills NFL Preseason Week 1 Game on August 13 2022

Where: Highmark Stadium in Orchard Park, NY

When: Saturday, August 13, 2022 at 4:00 PM ET

Betting on the Indianapolis Colts

In their most recent game on Sunday, January 9, 2022, the Colts lost to the Jacksonville Jaguars 26-11. The Colts gained 185 passing yards and averaged 5.22 yards per rush attempt. They had 2 turnovers and a possession time of 26:41. Does that bode well for them going into their game this week even though it’s a new season?

Absences and Injuries

As for inactive players, the Colts have zero injured players ruled out.

Betting on the Buffalo Bills

In their latest clash on Sunday, January 23, 2022, the Bills were defeated by the Kansas City Chiefs 42-36. The Bills gained 329 passing yards and averaged 4.54 yards per rush attempt. The team had 0 turnovers and a possession time of 27:37. We are excited to see what happens next in this coming season!

Absences and Injuries

The Bills have no injured players ruled out.

Indianapolis Colts vs Buffalo Bills | Moneyline, Over/Under and Point Spread Odds

Moneyline Pick: Indianapolis Colts (-120) at FanDuel

For this first preseason game, the Indianapolis Colts are considered the favorite. Can they secure the win? Or will the Buffalo Bills best them?

Over/Under Pick: Over 35 Points (-110) at FanDuel

The number of points, we estimate, will be over 35 for this preseason football game. Keep this in mind while placing your bet!

Spread Pick: Buffalo Bills 1 Points (-110) at FanDuel

The Buffalo Bills will need to lose by less than the amount of the spread or win outright in order to cover.

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